In Vitro Survival of Breast Cancer Cell Lines Following Chemotherapy or Radiotherapy in Comparison with Gold-mediated Phototherapy: Thesis Abstract

Thesis Abstract Background: Breast cancer is a heterogeneous disease that mandate efficient therapeutics, lower drug toxicity, and overcoming resistance. Combination therapy was suggested as future treatment to attain the required efficacy tolerable side effects. Aim: The current study aimed compare evaluate of single combined treatments in MCF-7 breast cell line. Materials Methods: included seven groups according modality. Cell viability evaluated by MTT assay at different doses time course treatments. Results: When nanoparticles were used alone, starting point significant death 100 µg, but when using photothermal combination modality loss % bout 2- fold higher than alone especially low concentrations there difference between 2 groups. There FAC + AuNPs group compared only or control (p ≤ 0.05). Taxol effect radiation on within all subgroups ( p < 0.001 for R0, p=0.001 R2 subgroup). each subgroup indicated values p= 0.027 RN0, RN2). Conclusion: Combined GNPs FAC, paclitaxel, Radiotherapy modalities could improve outcomes prognosis.